Among 13 patients hospitalized during their second infection, eight were males, with ages ranging from 44 to 95 years, and two had received two doses of vaccine. All patients reported comorbidities, six were transferred to ICU and two died (Supplementary Table 1). The proportion of each virus variant during the first and second COVID-19 episodes significantly differed, with the 20A.EU2 (B.1.160) variant being predominant during the first infection and the 21A (Delta) (B.1.617.2) variant being predominant during the second episode (Table 2). In patients experiencing a second infection, the 20I (Alpha.V1) (B.1.1.7), 20A.EU2 (B.1.160) and 21A (Delta) (B.1.617.2) variants accounted for more than 95% of viruses which genome was identified. Only seven patients were infected twice with the same variant (Supplementary Table 2). Six of them experienced mild infections and were not hospitalized. One patient was hospitalized during both episodes of infection and was transferred to ICU during the second episode.
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